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Kishan D. Patel ¹, Chhaganbhai N. Patel ², Grishma M. Patel ³

Affiliations
1 Shree S. K. Patel College of Pharmaceutical Education & Research, Gujarat, IN
2 Shri Sarvajanik Pharmacy College, Gujarat, IN
3 K. B. Institute of Pharmaceutical Education & Research, Gujarat, IN

Abstract

A new series of 4-((2,4-dioxathiazolidin-5-ylidine)methyl)substituted benzene sulphonamide was prepared. The purity of the new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H-NMR and mass spectroscopy. All the target compounds were evaluated for their in vivo antidiabetic activity on male Wistar rats by Oral Glucose Tolerance Test (OGTT) method using pioglitazone as standard. Amongst all, compound K17 and K18 exhibited more prominent antidiabetic activity. The results were statistically verified for its significance.

Keywords

2,4-Dioxathiazolidin, Antidiabetic, OGTT, Statistically Significant, Spectroscopy.

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Vimal I. Patel ¹, Harsha U. Patel ¹, Chhaganbhai N. Patel ¹, Kiran J. Suthar ¹

Affiliations
1 Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, IN

Abstract

4-(4-Substituted Phenyl)-5,6-Disubstituted-1-(4-Substituted Phenyl Thiazol-2-yl) Pyridin-2(1H)-One have been prepared from citric acid it is treated withconc. H₂SO₄ and then with phenetole to give β-arylglutaconic acid which on fusion with 2-amino 4-substituted Phenyl thiazole results in 4-(4-substitutedphenyl)-1-(4-substitutedphenylthiazol-2-yl) pyridine-2,6 (1H,3H)-dione. Then reacted with phosphorous oxychloride, it give 5,6-dichloro-4-(4-substituted phenyl)-1-(4 substituted phenyl thiazol-2-yl) pyridin-2(1H)-one. Which on treatment with secondary amines Yields 4-(4-Substituted phenyl)-5,6-Disubstituted-1-(4-Substituted-Phenyl thiazol-2-yl)Pyridin-2(1H)-One. All the title compounds characterised on the basis of their IR, MASS, ¹H NMR spectroscopic data analysis.

Keywords

Synthesis, Thiazole, β-Arylglutaconic Acid, Secondary Amines, Anti-Bacterial Activity.

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Kiran J. Suthar ¹, Harsha U. Patel ¹, Chhaganbhai N. Patel ¹, Vimal Patel ¹

Affiliations
1 Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, IN

Abstract

6, 8-Disubstituted-3-(4-(4-Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine have been prepared from 2-amino 4-substituted Phenyl thiazole react with substituted salicyladehyde results in 2,4-disubstituted-6-((4-(4- substituted phenyl) thiazol-2-ylimino) methyl) phenol. Then reacted with NaBH₄, it give 2,4-disubstituted-6-((4-(4-substituted phenyl) thiazol-2-ylamino) methyl) phenol. Which is reacted with fomalin in chloroform yields 6, 8-Disubstituted-3-(4-(4-Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine. All the title compounds characterised on the basis of their MASS, ¹H NMR spectroscopic data analysis.

Keywords

Synthesis, Thiazole, Salicyladehyde, Anti-Bacterial Activity.

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